🔬TODAY’S BREAKTHROUGH
Blood factors from young adults can rejuvenate human skin tissue in culture, reducing biological age and boosting regeneration signals in human tissue models.
The Discovery:
Using 3D co-cultures of human skin and bone marrow models, researchers found that serum from young donors dramatically increased skin cell proliferation and decreased methylation-based biological age as compared to aged serum. They identified 55 proteins secreted by bone-marrow cells that may mediate systemic rejuvenation.
The Science:
Young serum exposure led to faster skin cell growth and lower epigenetic age in tissue culture
Evidence of reduced markers of cellular senescence, improved extracellular matrix gene expression
Proteomic analysis isolated 55 candidate rejuvenating proteins produced by bone marrow-derived cells
The effect occurred only when combined skin and bone marrow cultures were used, indicating inter-tissue signaling mechanisms
Offers a rare glimpse into translatable human-specific rejuvenation pathways
Your Action:
While this was an in vitro study, it highlights the potential of bone marrow–derived circulating factors for skin and tissue rejuvenation. Support your body’s own systemic signaling by focusing on stem cell support, anti-inflammatory nutrition, and interventions that preserve bone marrow health and circulation, like regular activity, sleep quality, and nutrient-rich diets.
Bottom Line:
Substances in young human serum prompted skin regeneration and biological age reversal in human tissue models, highlighting systemic rejuvenation signals generated from bone marrow.
Source:
Systemic factors in young human serum influence in vitro rejuvenation of human skin and bone marrow models, Aging (Albany NY), 25 July 2025, Latumalea et al.
https://www.aging-us.com/article/206288/text
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.