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🔬TODAY’S BREAKTHROUGH
A groundbreaking study shows that low-frequency ultrasound (LFU) can reverse hallmarks of senescence in human cells and improve healthspan and lifespan in mice.
The Discovery:
Researchers applied 32.2 kHz ultrasound waves to senescent human fibroblasts, stem cells, and neurons. LFU restored cell growth, reduced inflammatory secretions, lengthened telomeres, and normalized key aging markers. In aged mice, regular LFU treatments reduced senescence markers in organs, boosted physical activity, and extended survival to nearly 3 years in some cohorts.
The Science:
LFU reversed over 15 hallmarks of senescence, including elevated p16, p21, β-galactosidase, ROS, γH2AX, H3K9me3, while also restoring and lengthening telomeres.
Autophagy and mitophagy were re-activated, while mTORC1 signaling was inhibited, restoring cellular homeostasis.
Piezo1 ion channels mediated Ca²⁺ entry and actin dynamics, essential for rejuvenation.
Normal cells exposed to LFU secreted factors that stimulated senescent cells, mimicking exercise-like rejuvenation effects.
In vivo, LFU-treated old mice showed lower p16/p21 levels, stronger fur, higher wheel activity, and significantly improved healthspan and lifespan.
Combination treatments (LFU + rapamycin or cytochalasin D) further enhanced rejuvenation effects.
Your Action:
This is an early-stage mechanistic study. Do not attempt ultrasound interventions outside controlled labs. Instead, adopt regular physical exercise, which similarly activates mechanosensitive pathways, autophagy, and mitochondrial health, all key to delaying senescence.
Bottom Line:
Non-invasive ultrasound pressure waves can rejuvenate senescent cells and extend lifespan in mice, opening a path toward mechanical anti-aging therapies.
Source:
Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low-Frequency Ultrasound. Aging Cell. Kureel SK, Maroto R, Aniqua M, Powell S, Singh E, Margadant F, Blair B, Rasmussen BB, Sheetz MP.
https://doi.org/10.1111/acel.70008
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.