Treat Aging To Fight Neurodegeneration

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🔬TODAY’S BREAKTHROUGH

A comprehensive review argues that ageing itself drives Alzheimer’s, Parkinson’s, ALS and related dementias, and that combining anti‑ageing interventions with disease‑specific therapy could better protect the brain.

The Discovery:

The authors frame the brain within a body‑wide network and show how age‑linked failures in proteostasis, mitochondria, nutrient sensing, inflammation, autophagy, and intercellular communication create proteinopathies and network collapse.

They outline clinical and preclinical evidence that multi‑target anti‑ageing strategies can slow or counter these drivers when paired with standard care.

The Science:

System drivers: ageing increases Aβ, tau, α‑synuclein, TDP‑43 burden via loss of proteostasis, mitochondrial dysfunction, and chronic inflammation.
Pathways to modulate: mTOR, AMPK, sirtuins, NAD+ metabolism, autophagy, and insulin or incretin signaling.
Lifestyle and diet: caloric restriction, time‑restricted feeding, and Mediterranean‑style dietary patterns act on mTOR, AMPK, inflammation, and mitochondria.
Pharmacology: evidence discussed for metformin, rapamycin, GLP‑1 receptor agonists, and NAD+ boosters such as NR and NMN.
Rejuvenation and repair: senolytics to reduce SASP, young plasma factors or plasma exchange, fecal microbiota transplantation, and stem cell approaches show preclinical and early clinical signals.
Clinical lens: trials increasingly combine systemic anti‑ageing levers with disease‑specific agents, aiming to prevent or slow decline rather than chase single proteins.

Your Action:

Prioritize daily levers that modulate these pathways: consistent exercise, sleep regularity, and a Mediterranean‑leaning diet.

When evaluating therapies or trials, look for designs that target multiple ageing mechanisms at once, and that report outcomes beyond single pathology, including function and cognition.

Bottom Line:

Neurodegeneration tracks the biology of ageing. Tackling ageing pathways plus disease targets is a pragmatic route to protect brain health.

Source:

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances, Signal Transduction and Targeted Therapy, Qiu Jiang, Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Army Medical University.
https://doi.org/10.1038/s41392-025-02145-7

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