🔬TODAY’S BREAKTHROUGH
The search for human longevity interventions has a new, intriguing candidate. A retrospective study on a supplement called Rejuvant found a remarkable average reversal of biological age in a group of human participants in less than a year.
The Discovery:
In a retrospective analysis of 42 individuals taking a formulation of alpha-ketoglutarate (AKG) and vitamins, branded as Rejuvant, for an average of 7 months, researchers found an average decrease in biological age of 8 years. The reduction was measured using the TruAge DNA methylation test.
The Science:
The study utilized DNA methylation (DNAm) clocks to monitor changes in biological age, which is an attractive biomarker for the aging process.
The supplement formulation for men included calcium alpha-ketoglutarate (CaAKG) and Vitamin A, while the women's formulation included CaAKG and Vitamin D.
The average 8-year reduction in biological age was found to be statistically significant, with a large majority of participants experiencing a decrease.
The study also suggests that individuals with a higher baseline biological age or chronological age may have the largest response to the supplement.
Your Action:
While these findings are noteworthy, it is important to remember this was a small, retrospective, and not placebo-controlled study. The best approach to healthy aging remains a holistic one. Focus on a balanced diet, regular exercise, and adequate sleep to support your body's anti-aging mechanisms.
Bottom Line:
A supplement containing alpha-ketoglutarate showed a significant reversal in human biological age, making it a promising candidate for further study.
Source:
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test, AGING, Oleksandr Demidenko, et al., November 30, 2021 https://doi.org/10.18632/aging.203736
How was today’s newsletter?
A Quick Favor:
We kindly ask you to check out the sponsor(s) that made this newsletter possible. Your support helps us continue sharing valuable insights and empowering your wellness journey.
Fact-based news without bias awaits. Make 1440 your choice today.
Overwhelmed by biased news? Cut through the clutter and get straight facts with your daily 1440 digest. From politics to sports, join millions who start their day informed.
LEARN MORE ABOUT OUR WORK
— Capilli Eternal
Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.