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🔬TODAY’S BREAKTHROUGH
A new review explores how targeting cellular senescence with senolytics, vaccines, and immune cell therapies may delay age-related diseases and extend healthspan.
The Discovery:
Senescent cells accumulate with age, driving inflammation, fibrosis, and chronic disease. This review outlines the latest senolytic drugs, natural compounds, engineered peptides, extracellular vesicle therapies, and immune-based approaches like CAR-T and senolytic vaccines, highlighting their potential and current limitations for translation into human longevity therapies.
The Science:
Cellular senescence: cells permanently stop dividing, resist apoptosis, and secrete pro-inflammatory SASP factors. Beneficial in wound healing, but harmful when chronic.
Small molecule senotherapeutics: Dasatinib + quercetin, navitoclax, fenofibrate, zoledronic acid, metformin, fisetin, rutin, procyanidin C1, FOXO4-DRI, PROTACs, KSL0608-Se.
Natural products: Flavonoids like fisetin, quercetin, luteolin, kaempferol, and grape seed extract show senolytic or senomorphic effects in mice.
Biologically derived strategies: Mesenchymal stem cell–derived extracellular vesicles and miRNA-based approaches reduce senescence burden in vitro and in mouse models.
Immune therapies: CAR-T cells targeting uPAR or NKG2DL clear senescent cells in aged mice and primates; vaccines against CD153 or GPNMB extend lifespan in progeroid models.
Clinical trials: Pilot studies of dasatinib + quercetin show functional improvements in pulmonary fibrosis and diabetic kidney disease; fisetin and quercetin are in ongoing trials.
Challenges: Senescence heterogeneity, lack of precise biomarkers, side effects of broad senolytics, and the dual role of senescence in repair versus disease.
Your Action:
Senolytic and immune therapies are experimental.
For now, protect your healthspan with proven interventions: exercise, balanced diet, sleep, and smoking avoidance. These influence inflammation, mitochondrial health, and metabolic pathways connected to senescence.
Bottom Line:
Clearing or reprogramming senescent cells may become a cornerstone of anti-aging medicine, but precision and safety remain key hurdles.
Source:
Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies. Journal of Translational Internal Medicine. Fu TE, Zhou Z.
https://doi.org/10.1515/jtim-2025-0005
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.