🔬TODAY’S BREAKTHROUGH
What if psilocybin, the compound behind certain psychedelic experiences, also helps cells live longer?
A new study brings surprise anti-aging results in mice.
The Discovery:
Researchers treated aged mice with low-dose psilocybin over several months and found significant extension of cellular lifespan across multiple tissues. Psilocybin-treated mice also demonstrated improved survival rates, with fewer age-related pathologies compared to controls.
The Science:
Chronic administration of psilocybin slowed age-related decline in markers of cellular senescence, including p16^Ink4a and SA-β-gal
Treated mice showed enhanced mitochondrial function, with more efficient energy production and reduced reactive oxygen species
Psilocybin reduced chronic inflammation, lowering blood levels of IL-6 and TNF-α
Mice receiving psilocybin lived ~15% longer than controls, with fewer signs of organ deterioration
Your Action:
While this study is in aged mice, it’s a promising step toward understanding psilocybin’s geroprotective potential.
Continue to prioritize well-supported practices like intermittent fasting, resistance training, and anti-inflammatory nutrition.
Keep an eye on ongoing human studies exploring psilocybin’s effects on neurodegenerative diseases and systemic aging.
Bottom Line:
Low-dose psilocybin extended cellular lifespan, reduced inflammation, and improved survival in aged mice, offering an unexpected pathway to longevity science.
Source:
Psilocybin treatment extends cellular lifespan and improves survival of aged mice, npj Aging, Kosuke Kato et al., Emory University / Baylor College of Medicine, July 8, 2025
https://doi.org/10.1038/s41514-025-00244-x
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.