🔬TODAY’S BREAKTHROUGH
A groundbreaking human trial demonstrates that therapeutic plasma exchange (TPE), especially when combined with intravenous immunoglobulin (IVIG), can reverse biological age by over 2 years, a major leap in aging science.
The Discovery:
In a single-blind, placebo-controlled study involving adults over 50, participants underwent different schedules of TPE. some also received IVIG. After only months of treatment, those who received TPE combined with IVIG saw an average biological age reduction of 2.61 years, as measured by multi-omic clocks (covering epigenome, proteome, metabolome, glycome, and immune biomarkers). The TPE-only group still saw a 1.32-year rejuvenation. Notably, participants with higher markers of poor health (e.g., glucose, liver enzymes) experienced larger age reversal.
The Science:
TPE removes plasma and replaces it with albumin solution or donor plasma
Adding IVIG significantly enhanced effects, dropping biological age by 2.61 yrs vs 1.32 yrs for TPE alone
Multi‑omic clocks include epigenetic age, proteomic, metabolomic, and immune-based biomarkers
Treatment reduced inflammation, reshaped immune cell composition, and lowered senescence-associated proteins
Individuals with adverse baseline health benefited most, but even healthier participants saw improved balance, strength, and molecular markers
The procedure was well tolerated, with minimal adverse events, two cases among >40 participants
Your Action:
While TPE+IVIG is not yet widely accessible for anti-aging use, these results reveal how blood cleansing strategies can reverse aging markers.
Continue supporting your plasma milieu through hydration, balanced dietary proteins, regular aerobic exercise, and anti-inflammatory nutrients like omega‑3s and polyphenols.
Stay tuned for clinical trials offering multi-omic biomarker tracking to personalize rejuvenation strategies.
Bottom Line:
A single therapeutic plasma exchange session, especially with IVIG, can reverse multi-pathway biological age, marking a pivotal advance in measurable human rejuvenation.
Source:
Multi‑Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‑Blinded Randomized Placebo‑Controlled Therapeutic Plasma Exchange, Aging Cell, María Cristina Fuentealba et al., Buck Institute & Circulate Health, July 3, 2025
https://doi.org/10.1111/acel.70103
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.