Physiological Age Tracker Predicts How Long You’ll Live

🔬TODAY’S BREAKTHROUGH

Aging isn’t just in your genes, your muscles, lungs, and reflexes may reveal more about your true biological age than your birthday.

Scientists from the University of Lausanne have created a physiological clock that predicts biological age using 12 routine body function tests. Drawing on data from over 300,000 UK Biobank participants, the model identified a trait-based aging score (ΔAge) that closely tracked mortality risk, parental longevity, and known genetic and environmental influences. The findings offer a non-invasive alternative to methylation-based aging clocks.

• The clock uses 12 physiological traits, including blood pressure, lung function (FEV1), grip strength, BMI, cholesterol, cognitive reaction time, and albumin

• Individuals with higher ΔAge (biological age > chronological age) had significantly increased mortality risk over 10 years

• Lower ΔAge (biological age < chronological age) correlated with longer parental lifespan, suggesting inherited resilience

• Environmental and lifestyle factors, including smoking, sleep, and physical activity, showed strong influence on physiological aging speed

• Unlike epigenetic clocks, this model is lab-accessible, using standard clinical data instead of DNA methylation profiles

Track and optimize key metrics like grip strength, lung capacity, and reaction time as proxies for biological resilience.

Sleep well, avoid smoking, and stay physically active, these factors directly slow your physiological age progression.

Simple physical tests may now tell you more about your future health and longevity than your genes alone.

A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging, eLife, University of Lausanne, June 11, 2025
https://pubmed.ncbi.nlm.nih.gov/40497443/

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