🔬TODAY’S BREAKTHROUGH
What if a simple nutritional supplement could reverse years of cellular aging?
A new human trial shows that exogenous nucleotides significantly slowed biological aging and improved metabolic health in older adults.
The Discovery:
The TALENTs trial, a 19‑week double‑blind randomized study in 121 participants aged 60–70, examined daily supplementation with 1.2 g nucleotides (NTs) versus placebo.
Results showed a significant reduction of 3.08 years in DNA methylation age, meaning treated individuals aged slower on a cellular level. They also saw improved insulin sensitivity, with no severe side effects reported.
The Science:
NT supplementation led to –3.08 years change in DNA methylation clock vs. placebo (β = –3.08 yrs; P = 0.0023)
A trend toward reduced DNA methylation age appeared after 11 weeks (β = –1.94 yrs; P = 0.11)
No significant change in leukocyte telomere length in either group
HOMA‑IR (insulin resistance) improved (β = –0.45; P = 0.033) for the NT group
No severe adverse events, indicating a well‑tolerated safety profile
Your Action:
Consider integrating nucleotide-rich foods (e.g., meat, fish, legumes) or researched NT supplements into your daily routine. Pair supplementation with metabolic support, fiber-rich diet, regular exercise, and consistent sleep, to amplify metabolic and longevity benefits.
Bottom Line:
Nucleotide supplementation in older adults significantly reversed biological aging by approximately three years and enhanced insulin sensitivity, without adverse effects.
Source:
Nucleotides as an Anti‑Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs), Advanced Science (Weinh), Shuyue Wang et al., Peking University, May 28, 2025
https://doi.org/10.1002/advs.202417728
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.