🔬TODAY’S BREAKTHROUGH
In a first-of-its-kind human trial, nicotinamide riboside (NR), a precursor to the vital molecule NAD+, showed multiple health benefits in patients with Werner syndrome, a rare premature-aging condition.
The Discovery:
Researchers in Japan conducted a randomized, double-blind crossover trial on adults with Werner syndrome, administering 1,000 mg/day of NR or placebo for 26 weeks before switching.
NR supplementation significantly increased blood NAD+ levels, improved arterial stiffness, reduced skin ulcer size, and slowed kidney decline, all without serious side effects
The Science:
NR increased NAD+, essential for DNA repair, energy metabolism, and cell longevity
Cardio–ankle vascular index (CAVI) improved, indicating healthier arteries
Skin ulcers shrank, suggesting enhanced tissue repair
Creatinine levels fell and renal function stabilized, hinting at kidney support
No serious adverse events, demonstrating good safety in this cohort
Your Action:
Although targeted to a rare condition, this study highlights NAD+ as a powerful biological lever.
Consider exploring dietary precursors like tryptophan-rich foods, exercise, and safe supplements that support NAD+ metabolism.
Bottom Line:
Supplementing NAD+ with NR showed measurable improvements in cardiovascular, skin, and kidney health, a promising human proof of concept for longevity interventions.
Source:
Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial, Aging Cell, Mayumi Shoji et al., Chiba University / University of Copenhagen, June 3 2025
https://doi.org/10.1111/acel.70093
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.