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🔬TODAY’S BREAKTHROUGH
Beyond DNA, your RNA may hold the deepest secrets to your biological age. Scientists have developed a new transcriptomic clock, TraMA, that uses gene expression data to predict your risk of mortality and various age-related conditions.
The Discovery:
Researchers at the University of Southern California introduced Transcriptomic Mortality-risk Age (TraMA), an RNA-based measure of biological aging. Developed by analyzing RNA sequencing data from nearly 4,000 U.S. adults (50+ years), TraMA accurately predicts the probability of early death within four years, the onset of multiple chronic diseases, and cognitive decline.
The Science:
TraMA is a novel RNA-based aging measure that estimates biological age from gene expression data.
It proved a strong and independent predictor of early death, chronic diseases, poor cognitive function, and difficulties with daily activities.
The clock tracks biological processes related to inflammation, immune function, and kidney and brain health, key systems in aging.
TraMA scores are sensitive to lifestyle factors: smoking, obesity, and low physical activity were associated with older TraMA scores.
Unlike DNA-based clocks, TraMA captures dynamic changes in biological aging as health evolves.
Your Action:
While TraMA is a research tool, its insights reinforce the power of lifestyle:
Prioritize anti-inflammatory living through diet (e.g., rich in fruits, vegetables) and stress management.
Stay physically active and maintain a healthy weight to positively influence your transcriptomic age.
Avoid smoking, which is linked to accelerated TraMA scores and overall aging.
Bottom Line:
Your gene expression patterns can reveal your true aging trajectory. The TraMA clock highlights how inflammation, immune health, and lifestyle are measurable drivers of longevity.
Source:
Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA), Aging (Albany NY), Eric T. Klopack et al., June 13, 2025
https://www.aging-us.com/article/206272/text
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.