🔬TODAY’S BREAKTHROUGH
A one‑year trial found that a natural supplement regimen, paired with light walking and mindfulness, reduced participants’ epigenetic age and enhanced physical performance and immune profiles.
The Discovery:
In a single-arm clinical trial of 51 adults, a proprietary nutraceutical blend alongside 10-minute daily walks and 5 minutes of mindfulness led to measurable drops in biological age, assessed via multiple DNA methylation clocks, plus gains in muscle strength, mobility, and lean body mass.
The Science:
Stem cell division slowed, as evidenced by reduced epiTOC2 mitotic clock signals
Immune profiling showed increased eosinophils and CD8⁺ T-cells, with decreases in memory B cells, regulatory T cells, and CD4⁺ T memory cells
Participants saw improvements in grip, chair-stand, toe-touch, Timed Up & Go, and one-leg stand tests
Mass composition improved: more lean mass, less body fat
CpG methylation sites shifted in genes linked to oxidative stress, senescence, neurotransmission, and collagen synthesis
Your Action:
Support these hallmarks with:
A plant-rich micronutrient supplement containing antioxidants (e.g., astragaloside, rutin), methyl donors (B12, folate), trace minerals (zinc, selenium), and NAD⁺ precursors.
Daily short walks (≥10 min) and mindfulness practice (≥5 min) to synergize with supplementation.
Regularly monitor physical function (e.g., grip, chair-stand tests), body composition, and immune cell ratios if available.
Bottom Line:
A combined supplement-walk-mindfulness regimen reduced biological age and enhanced physical and immune health in adults, supporting an integrative path to rejuvenation.
Source:
Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks, physical function, and body composition: a single-arm clinical trial, Aging (Albany NY), Carreras‑Gallo et al., March 14, 2025
https://doi.org/10.18632/aging.206221
How was today’s newsletter?
LEARN MORE ABOUT OUR WORK
— Capilli Eternal
Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.