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A new human clinical study reveals that pterostilbene, a natural molecule found in blueberries, can significantly improve visible signs of skin aging in just 28 days, pointing to a new direction in cosmetic science.

The Discovery:

In a 28-day double-blind, split-face trial involving 31 participants, Chinese researchers tested a skincare emulsion containing 0.1% pterostilbene against a control. The pterostilbene formulation remarkably improved skin firmness, elasticity, and reduced wrinkles (forehead, undereye, crow's feet) while also increasing epidermis thickness and enhancing collagen and elastic fibers.

The Science:

  • Pterostilbene is a natural antioxidant found in blueberries, structurally similar to resveratrol.

  • The double-blind, split-face design (pterostilbene on one side, placebo on the other) ensured unbiased results.

  • Significant improvements were observed in skin elasticity, firmness, and wrinkle reduction.

  • It also increased epidermis thickness, a marker of youthful skin, and boosted collagen and elastic fibers.

  • Subjects reported higher satisfaction with the pterostilbene emulsion compared to the control.

  • The study suggests multiple mechanisms for its anti-aging efficacy in skin.

Your Action:

Consider looking for skincare products containing pterostilbene if you're interested in topical anti-aging. As a natural antioxidant, it aligns with broader health goals. Remember that topical application differs from oral supplementation, and consistent use is key for visible results.

Bottom Line:

Pterostilbene offers a potent, natural solution for visibly reversing skin aging signs in humans, opening new avenues for science-backed skincare.

Source:

Anti-aging Efficacy of a 0.1% Pterostilbene Skincare Emulsion: A 28-Day Clinical Trial, Journal of Dermatologic Science and Cosmetic Technology, Zongxiao Cen et al., May 20, 2025
https://doi.org/10.1016/j.jdsct.2025.100083

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Disclaimer:

This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.

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