Hello Capilli Eternal Community,

In today’s newsletter, we explore NAD⁺ , the molecule critical for energy production, DNA repair, and overall cellular health. You’ll discover why NAD⁺ levels decline with age, its role in longevity, and actionable strategies to boost your levels naturally and safely.

Let’s dive into the science behind vitality!

What Is NAD⁺

NAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme essential for life. Found in every cell, it acts as a helper molecule in critical processes:

1. Energy Production: NAD⁺ enables mitochondria to convert food into ATP (cellular energy).

2. DNA Repair: Activates enzymes like PARPs to fix damaged DNA and maintain genomic stability.

3. Longevity Proteins: Regulates sirtuins, which play a role in metabolism, stress resistance, and lifespan.

Why NAD⁺ Levels Decline with Age

By the time you’re 50, NAD⁺ levels in your cells can be as much as 50% lower than in your youth. This decline is linked to:

• Oxidative Stress: Accumulated damage from free radicals depletes NAD⁺ reserves.

• Inflammation: Chronic inflammation accelerates the breakdown of NAD⁺ .

• Environmental Toxins: Exposure to pollution and chemicals disrupts cellular processes.

• Poor Sleep: Sleep deprivation interferes with NAD⁺ synthesis pathways.

Sources:

• Roles of NAD+ in Health and Aging

• It takes two to tango: NAD+ and sirtuins in aging/longevity control

The Role of NAD⁺ in Longevity

NAD⁺ supports proteins like sirtuins, which regulate cell health, inflammation, and stress response. Low NAD⁺ is associated with fatigue, slower recovery, and increased susceptibility to age-related diseases.

Research Highlights:

1. Sirtuins and Longevity: A Harvard study found that NAD⁺ enhances sirtuin activity, promoting metabolic health and longevity.

2. NAD⁺ Precursors: Clinical trials on NMN and NR show they can restore NAD⁺ levels and improve mitochondrial efficiency.

Watch This:
A concise explanation from a leading expert on aging.

How to Support NAD⁺ Levels Naturally

1. Lifestyle Strategies:

   • Intermittent Fasting: Activates pathways that conserve and boost NAD⁺ .

   • Exercise: High-intensity interval training (HIIT) and resistance training stimulate mitochondrial function and increase NAD⁺ .

   • Sleep Hygiene: Aim for 7–8 hours of quality sleep to optimize NAD⁺ production.

2. Nutritional Tips:

   • Include NAD⁺ -boosting foods like turkey, salmon, avocado, and green vegetables.

   • Reduce processed sugars and refined carbs to lower oxidative stress.

3. Supplements:

   • NMN (Nicotinamide Mononucleotide): Converts directly into NAD⁺ in cells.

   • NR (Nicotinamide Riboside): A precursor that has been shown to elevate NAD⁺ levels.

Tip: Look for third-party-tested brands to ensure quality and safety.

Actionable Protocol: Boost Your NAD⁺ Today

Morning Routine:

• Fast for 16 hours (e.g., stop eating at 8 PM, resume at noon).

• Start your day with a 20-minute brisk walk or light cardio.

Meal Plan:

• Include a salad with dark leafy greens, avocado, and a lean protein like salmon.

Evening Routine:

• Turn off screens an hour before bed to minimize blue light exposure.

• Take a magnesium supplement to promote restful sleep.

Supplement Consideration:

• NMN or NR: Consult with a healthcare provider about incorporating NAD⁺ precursors into your regimen.

Tracking Your Progress:

• Consider testing NAD⁺ levels with at-home biomarker kits like Elysium Index or InsideTracker for personalized insights.

What’s Next?

In our next newsletter, we’ll explore the latest research on NAD⁺ supplementation and its implications for health and longevity.

Thank you for being part of the Capilli Eternal. Together, we’re transforming health through knowledge and action.

To your vitality,

The Capilli Eternal Team