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🔬TODAY’S BREAKTHROUGH
What does the body of a 117-year-old who never developed cancer or dementia look like at the molecular level? Scientists now have the answer.
The Discovery:
In a groundbreaking multiomics study, researchers analyzed the genome, epigenome, transcriptome, metabolome, proteome, and microbiome of the oldest verified human in history. Despite signs of extreme chronological aging, this supercentenarian exhibited a unique biological profile associated with low inflammation, strong immune function, younger epigenetic age, and resilient genetic variants.
The Science:
Telomeres were extremely short, yet no cancer or degenerative diseases occurred
Identified rare genetic variants tied to immune regulation, cognition, and mitochondrial efficiency
Despite mutations associated with clonal hematopoiesis, no tumors developed
B cell populations were aged, but T cell memory and cytotoxicity were strong and youthful
Lipid metabolism was highly efficient, with exceptionally high HDL and low VLDL levels
Blood showed very low systemic inflammation, including low GlycA and GlycB levels
Her microbiome resembled that of much younger individuals, with high Bifidobacterium
Epigenetic clocks in blood, saliva, and urine estimated her biological age as decades younger
DNA methylation profiles showed preservation of chromosomal stability and repeat silencing
Your Action:
Prioritize anti-inflammatory foods and maintain a Mediterranean-style diet with fermented foods like yogurt.
Support mitochondrial and cardiovascular health through regular movement.
Protect your epigenome with quality sleep and stress reduction.
Consider microbiome-targeted strategies such as probiotics or prebiotic fiber.
Bottom Line:
Extreme longevity may emerge when disease biology and aging biology decouple, revealing powerful new targets for healthy aging.
Source:
The multiomics blueprint of the individual with the most extreme lifespan, Cell Reports Medicine, Santos-Pujol et al.
https://doi.org/10.1016/j.xcrm.2025.102368
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.