Hello Capilli Eternal Community,
As we age, chronic inflammation doesn’t just exhaust the body, it rewires our stem cells. Scientists have now traced a direct line from inflammation to stem cell death and loss of regenerative muscle capacity.
🎯 Today’s Breakthrough
The Discovery:
A new study shows that age-related inflammation erodes a critical epigenetic mark in muscle stem cells. This erosion disables genes that prevent ferroptosis, an iron-driven form of cell death. Without those defenses, stem cells accumulate toxic damage, lose quiescence, and die. Anti-inflammatory therapy reversed the process in mice, restoring muscle regeneration.
The Science:
Inflammation suppresses Kmt5a, the enzyme responsible for depositing H4K20me1
Loss of H4K20me1 shuts down ferroptosis-resistance genes in muscle stem cells
Aged stem cells accumulate iron and lipid peroxides, triggering ferroptosis
Treating aged mice with Bindarit restored H4K20me1, preserved stem cell quiescence, improved muscle regeneration, and functional recovery
Your Action:
Reduce chronic inflammation through lifestyle: eat Mediterranean-style meals rich in polyphenols and omega-3s, maintain consistent sleep, and manage stress daily.
Ask your doctor to monitor inflammatory markers like CRP and explore long-term strategies to keep them in a healthy range.
Bottom Line:
Controlling chronic inflammation may help preserve your body’s ability to regenerate by protecting stem cells from iron-driven, inflammation-induced cell death.
Source:
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis, Nature Aging, Roméo S. Blanc et al., June 30, 2025
https://www.nature.com/articles/s43587-025-00902-5
To your health and vitality,
Capilli Eternal
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.