🔬TODAY’S BREAKTHROUGH
Daily β‑hydroxybutyrate (3HB) supplementation was shown to delay cellular senescence and extend lifespan by over 20% in aged mice, revealing a powerful metabolite-driven anti-aging strategy.
The Discovery:
Researchers daily administered 3HB to naturally aging mice. After treatment, they observed a median lifespan increase of 21%, with improved healthspan markers in kidney and muscle tissues. The intervention also reduced SA‑β‑gal (senescence-associated β-galactosidase) activity, a key marker of cellular aging.
The Science:
3HB delayed cellular senescence in primary cell models (2BS and WI‑38 fibroblasts) and yeast, then replicated in aged mice
Senescence marker SA‑β‑gal activity decreased significantly in treated kidneys and colon tissues
A 21% median lifespan extension (123 days) was accompanied by enhanced grip strength and stabilized body weight during aging
Metabolomic profiling revealed increases in trigonelline and isoguvacine, metabolites linked to anti-senescence effects
Mechanistically, 3HB reprogrammed metabolism and delayed senescence, providing a “clean” longevity intervention without toxicity
Your Action:
Support similar benefits through:
Intermittent fasting or ketogenic cycles to raise endogenous 3HB
Medium-chain triglyceride (MCT) oil or exogenous ketone supplements, under supervision
Maintaining exercise, hydration, and balanced protein intake to support metabolism
Bottom Line:
β‑Hydroxybutyrate is a natural metabolite that reverses cell senescence and extends lifespan in mice, making it a promising candidate for safe, metabolic anti-aging interventions.
Source:
Unveiling the Anti-Aging Potential of 3HB: Lifespan Extension and Cellular Senescence Delay, Nutrients, An et al., May 12, 2025
https://doi.org/10.3390/nu17101647
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.