🔬TODAY’S BREAKTHROUGH
A new review shows how metabolic interventions, from mitochondria-targeted therapies to dietary strategies, may not only slow but potentially reverse age-related cognitive decline.
The Discovery:
Researchers outline how metabolic dysfunction, in mitochondria, insulin signaling, and lipid balance, drives neurodegeneration. They highlight emerging therapies such as caloric restriction, rapamycin, NAD+ boosters, and mitochondrial antioxidants as promising tools to restore neuronal resilience and protect cognition.
The Science:
Mitochondrial dysfunction causes energy deficits, oxidative stress, and disrupted dynamics in aging neurons.
Brain insulin resistance impairs glucose metabolism, worsens amyloid and tau pathology, and fuels neurodegeneration.
Lipid dysregulation alters cholesterol and fatty acid metabolism, triggering inflammation and synaptic injury.
Interventions: caloric restriction, fasting, ketogenic diets, metformin, rapamycin, spermidine, NAD+ boosters, AMPK activators, and mitochondria-targeted drugs.
Precision medicine: metabolomics and lipidomics may enable tailored metabolic therapies for patients at risk of dementia.
Your Action:
Support brain metabolism with lifestyle interventions: balanced diet, regular exercise, and periods of fasting or calorie moderation.
These approaches help preserve mitochondrial health and improve insulin sensitivity.
Bottom Line:
Targeting metabolism is emerging as a powerful strategy to combat cognitive decline.
Source:
Harnessing Metabolism to Combat Neurodegeneration: Strategies for Reversing Age-Related Cognitive Decline. ACS Pharmacology & Translational Science. Jain S, Acharya R, Verma L, Chauhan A. Published: July 31, 2025.
https://doi.org/10.1021/acsptsci.5c00077
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.