🔬TODAY’S BREAKTHROUGH
A new mouse study shows that geranylgeraniol (GGOH) supplementation may reverse age-related muscle loss and rejuvenate mitochondrial function, two key drivers of healthy aging.
The Discovery:
Researchers treated aged mice (20–24 months) with daily geranylgeraniol, a natural isoprenoid compound, over 12 weeks. Compared to controls, treated mice regained up to 20% of lost muscle mass, exhibited enhanced endurance performance, and restored mitochondrial respiration efficiency in skeletal muscle, addressing two core hallmarks of aging.
The Science:
GGOH supports protein prenylation, a process declining with age, crucial for proper mitochondrial dynamics.
Treated mice showed significantly increased grip strength (by ~18%) and treadmill endurance (by ~25%).
Mitochondrial assays revealed improved maximal respiratory capacity and reduced reactive oxygen species (ROS) release.
Biopsy showed downregulation of atrophy markers (e.g., MaFbx and Murf1) and improved expression of mitochondrial biogenesis gene PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1‑alpha).
Histological analysis confirmed larger muscle fiber cross-sectional area and reduced lipid accumulation in aged muscle.
Your Action:
While GGOH is not yet tested in humans, maintain robust muscle and mitochondrial health through daily resistance training, intermittent fasting, and nutrient-rich intake of coenzyme Q10, omega‑3s, and plant polyprenols (e.g., in olive oil, green tea). These dietary strategies support similar mitochondrial and muscle pathways.
Bottom Line:
Supplementing with geranylgeraniol reversed muscle and mitochondrial aging in mice, offering a promising avenue for future human therapies.
Source:
Geranylgeraniol supplementation reverses sarcopenia by enhancing mitochondrial function in aged mice, Mechanisms of Ageing and Development, Li Wang et al., University of California, San Diego, June 25, 2025
https://doi.org/10.1016/j.mad.2025.111501
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.