🔬TODAY’S BREAKTHROUGH
A new study explores the potential of a single gene therapy treatment to fight aging on multiple fronts. By increasing levels of the Klotho protein, researchers have successfully extended both the lifespan and healthspan of mice.
The Discovery:
Scientists delivered a gene therapy vector coding for the secreted Klotho (s-KL) protein to wild-type mice. This single treatment resulted in a statistically significant 20% increase in lifespan in male mice. It also improved physical fitness, bone health, and neurological function.
The Science:
The s-KL protein was delivered using an adeno-associated virus (AAV9) vector, which efficiently increased s-KL concentration in the serum.
Treated mice showed improved physical capacities, which was linked to a reduction in muscle fibrosis and increased muscular regenerative capacity.
The treatment improved bone microstructural parameters, an effect associated with osteoporosis.
s-KL-treated mice also exhibited increased cellular markers of adult neurogenesis and immune response in the aged hippocampus.
Transcriptomic analysis revealed increased phagocytosis and immune cell activity in the aged hippocampus of treated mice, without a corresponding increase in pro-inflammatory signals.
Your Action:
While this therapy is in early research stages, it highlights the importance of multi-system health. To support your body's anti-aging mechanisms, focus on a healthy lifestyle. Regular exercise, a balanced diet, and adequate sleep all help reduce inflammation and maintain muscle, bone, and cognitive health.
Bottom Line:
A single gene therapy targeting the Klotho protein shows potential to simultaneously slow age-associated degeneration in multiple organs.
Source:
Long-term effects of s-KL treatment in wild-type mice: Enhancing longevity, physical well-being, and neurological resilience, Molecular Therapy, Joan Roig-Soriano and Miguel Chillón, et al., April 2025 https://doi.org/10.1016/j.ymthe.2025.02.030
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.