In partnership with
🔬TODAY’S BREAKTHROUGH
A major U.S. study finds that accelerated epigenetic aging in blood predicts slower thinking and lower cognitive performance by midlife.
The Discovery:
Researchers from the University of Illinois Chicago, Tulane University, and collaborators analyzed data from 1,252 middle-aged adults in the Bogalusa Heart Study. They found that people with higher GrimAge acceleration, a DNA methylation-based measure of biological aging, had significantly slower processing speed and lower global cognition. Genetic evidence supported a potential causal role, linking faster epigenetic aging to impaired brain function even before old age.
The Science:
The team assessed four major epigenetic age acceleration (EAA) markers: Horvath’s IEAA, HannumAA, PhenoAA, and GrimAA.
Higher GrimAA, HannumAA, and PhenoAA were all associated with slower attention and processing speed after adjusting for lifestyle and health factors.
GrimAA showed the strongest link, also correlating with lower global cognition scores.
A Mendelian randomization analysis using GWAS data of over 100,000 participants suggested a genetic predisposition to faster GrimAA might causally impair processing speed.
The association appeared stronger in women, pointing to possible sex-specific pathways in cognitive aging.
Your Action:
Support your brain’s biological youth by keeping your epigenetic age low. Regular exercise, sufficient sleep, a healthy diet, and stress reduction can positively influence DNA methylation patterns. Periodic testing of biological age may help you monitor progress and risk.
Bottom Line:
Your epigenetic age, not your birth age, may predict how quickly your thinking slows in midlife.
Source:
Epigenetic age acceleration and midlife cognition: joint evidence from observational study and Mendelian randomization, npj Aging, Yang Pan et al., University of Illinois Chicago & Tulane University, 2025.
https://doi.org/10.1038/s41514-025-00265-6
How was today’s newsletter?
A Quick Favor:
We kindly ask you to check out the sponsor(s) that made this newsletter possible. Your support helps us continue sharing valuable insights and empowering your wellness journey.
Buying Cannabis Online Is Now Legal, And Incredibly Convenient
For years, buying cannabis meant taking a trip to a dispensary, dealing with long lines, limited selection, and inconsistent pricing. But thanks to changing laws and innovative online retailers, buying high-quality THC products is now 100% federally legal—and more convenient than ever.
And when it comes to quality and reliability, Mood is leading the way…
Because they’ve completely flipped the script on cannabis shopping. Instead of memorizing hundreds of confusing strain names – like “Gorilla Glue” and "Purple Monkey Breath" – you simply choose how you want to feel: Creative, Social, Focused, Relaxed, Happy, Aroused, and more.
Each gummy is formulated with the perfect blend of Delta-9 THC and botanicals to deliver the perfect mood.
Want a great night’s sleep? Try the Sleepytime gummies. Need laser focus Mind Magic gummies have you covered. Hotter sex? Try the Sexual Euphoria gummies.
It's cannabis shopping that actually makes sense for “normal” people.
LEARN MORE ABOUT OUR WORK
— Capilli Eternal
Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.