🔬TODAY’S BREAKTHROUGH
Could a blood test reveal your future health potential?
A new study delivers just that, introducing an epigenetic clock that measures your intrinsic capacity, a marker of physical and mental resilience and predicts long-term outcomes.
The Discovery:
Researchers developed and validated a novel intrinsic capacity epigenetic clock using blood DNA methylation patterns. In large cohorts, individuals with older intrinsic capacity scores faced significantly higher risks of mortality, frailty, cognitive decline, and decreased physical performance. The clock also correlated with key immune markers, inflammation, and lifestyle factors.
The Science:
Built from methylation profiles in immune-related genes tied to physical and cognitive resilience
Validated across cohorts including UK Biobank and Rotterdam Study, confirming predictive link to all-cause mortality
Strong associations found with markers like CRP, interleukin-6, and T-cell profiles
Higher intrinsic capacity ages corresponded to worse physical performance tests and cognitive assessments
The clock is independent of chronological age and traditional epigenetic clocks, measuring a unique resilience-related aging dimension
Your Action:
Consider getting an epigenetic test that measures intrinsic capacity if it becomes available.
More immediately, support resilience by maintaining balanced nutrition, engaging in strength and cognitive training, and reducing chronic inflammation through sleep, stress control, and anti-inflammatory foods.
These interventions may counteract declines detected by such a clock.
Bottom Line:
A blood-based epigenetic clock for intrinsic capacity provides a powerful, early indicator of resilience and longevity risk, offering a new benchmark for proactive aging care.
Source:
A blood‑based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors, Nature Aging, Lisa M. McCartney et al., University of Edinburgh, June 4, 2025
https://doi.org/10.1038/s43587-025-00883-5
How was today’s newsletter?
LEARN MORE ABOUT OUR WORK
— Capilli Eternal
Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.