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🔬TODAY’S BREAKTHROUGH
A large UK Biobank study reveals that people who age faster biologically face higher risks of developing both atrial fibrillation and dementia, highlighting biological age as a powerful early warning signal.
The Discovery:
Researchers from Capital Medical University and Peking University analyzed over 402,000 participants and found that those with accelerated biological aging were significantly more likely to develop atrial fibrillation, dementia, and especially both conditions together. Unlike chronological age, this biological age marker captured how fast a person’s body is truly aging, and predicted disease transitions years in advance.
The Science:
Biological age was calculated using PhenoAge, derived from 9 blood biomarkers (including glucose, C-reactive protein, albumin, and white blood cell count).
Participants with high PhenoAge acceleration had up to a 66% higher risk of death after developing atrial fibrillation.
Each 1 standard deviation increase in biological age acceleration raised the risk of AF-to-dementia transition by 15%, and comorbidity-to-death by 9%.
PhenoAge acceleration improved prediction accuracy beyond chronological age and the validated CHARGE-AF clinical score.
Faster biological aging likely reflects endothelial cell senescence, vascular dysfunction, and inflammation, which jointly damage the brain and heart.
Your Action:
Biological aging is driven by lifestyle and health choices. Keep it slow by maintaining healthy glucose, blood pressure, and inflammation levels. Exercise regularly, reduce chronic stress, and eat nutrient-dense, low-sugar foods.
Ask your doctor about biological age testing or PhenoAge-based assessments to monitor how fast your body is aging, not just how old you are.
Bottom Line:
Your biological age predicts how soon age-related diseases may overlap. Slowing it could protect both your heart and brain.
Source:
Utility of biological aging acceleration in capturing transitions of atrial fibrillation and dementia: a population-based study, npj Aging, Yufan Liu & Chenglong Li, Capital Medical University and Peking University
https://doi.org/10.1038/s41514-025-00274-5
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.