🔬TODAY’S BREAKTHROUGH
A new review highlights how targeting immunosenescence and inflammaging, two hallmarks of immune aging, could delay age-related decline and extend both healthspan and lifespan.
The Discovery:
Aging weakens immune defenses (immunosenescence) while fueling chronic low-grade inflammation (inflammaging). Together, these changes drive frailty and age-related diseases. Scientists now show that restoring thymic function, rejuvenating hematopoietic stem cells, modulating T cells, and targeting inflammatory pathways like IL-11 and TLR5/7 may rebalance the immune system and slow biological aging.
The Science:
Immunosenescence: Aging reduces barrier integrity, shrinks the thymus, weakens innate and adaptive immune responses, and depletes naive T and B cells.
Inflammaging: Senescent cells release SASP factors (IL-6, IL-8, IL-1β), while metabolic dysfunction and gut microbiome changes amplify systemic inflammation.
Interventions:
Thymus rejuvenation: FOXN1, IL-7, stem cells, and organoids restore T cell production.
HSC rejuvenation: Targeting p38 MAPK, Cdc42, or epigenetic reprogramming restores immune cell function.
T cell therapies: Telomere transfer, mTOR inhibitors, Dasatinib + Quercetin, and checkpoint inhibitors improve surveillance.
Senolytics & anti-inflammatory agents: CAR-T senolytics, fisetin, navitoclax, JAK inhibitors, and rapamycin clear senescent cells and reduce SASP.
Geroprotectors: Metformin, rapamycin, NAD+ boosters, and spermidine enhance immune resilience.
Novel targets: Blocking IL-11 reduces fibrosis and systemic inflammation; activating TLR5 and TLR7 boosts mucosal immunity and restores antiviral defenses.
Your Action:
Protect immune balance daily: keep inflammation low with nutrient-rich foods, physical activity, sleep, and stress control, while supporting immunity with healthy microbiome habits like fiber and fermented foods.
Bottom Line:
Targeting immune aging may become a cornerstone of longevity therapies, rebalancing defenses and inflammation to extend healthspan.
Source:
Targeting immunosenescence and inflammaging: advancing longevity research. Experimental & Molecular Medicine. Nguyen TQT, Cho KA, et al.
https://doi.org/10.1038/s12276-025-01527-9
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.