Hello Capilli Eternal Community,

Inside every one of your cells is a built-in self-cleaning system, a biological housekeeping protocol that disassembles what’s old, damaged, or dysfunctional.

It’s called autophagy.

The word comes from the Greek auto (self) and phagein (to eat). Autophagy literally means “self-eating.” But what it really means is self-renewal.

And fasting is one of the most powerful triggers we know for turning this system on.

What Is Autophagy?

Autophagy is a natural process your cells use to:

• Break down damaged proteins and cell components

• Recycle their parts to build new, healthier ones

• Eliminate toxic buildup before it causes disease

It is your body’s way of performing deep maintenance, like deleting corrupted files, clearing memory, and upgrading internal software.

This process:

• Protects against neurodegeneration

• Suppresses tumor development

• Slows aging

• Boosts immune defense

But here’s the problem:

Autophagy only kicks in when your cells sense scarcity.

When you’re constantly eating, the signal for autophagy stays turned off.

How Fasting Triggers Cellular Renewal

Fasting creates the precise biological stress that tells your cells it’s time to clean house.

After 12–16 hours without food:

• Nutrient sensors like mTOR are suppressed

• AMPK and sirtuins are activated

• Autophagy is initiated at a cellular level

As the fast continues, autophagy deepens, clearing out waste, recycling old components, and rebuilding younger, stronger cells from the inside.

It’s not a detox.

It’s not a trend.

It’s a deeply conserved evolutionary response designed to keep you healthy through periods of scarcity.

The Nobel Prize and Scientific Evidence

In 2016, Japanese biologist Dr. Yoshinori Ohsumi won the Nobel Prize for discovering the genes responsible for autophagy.

Since then, research has confirmed that enhanced autophagy can:

• Delay age-related diseases

• Improve metabolic flexibility

• Promote tissue and organ regeneration

• Protect against infections and immune dysfunction

Autophagy is not a fringe concept, it is foundational biology.

Longevity, Inflammation, and Beyond

When autophagy is working well, you:

• Age more slowly

• Clear senescent (zombie) cells

• Maintain stronger immunity

• Regulate blood sugar and cholesterol

• Support mental clarity and energy

When it’s blocked, by overeating, stress, and poor sleep, you accumulate damage, lose resilience, and age faster.

Can You Trigger Autophagy Without Fasting?

Some research suggests that:

• Exercise

• Ketosis

• Cold exposure

• Certain polyphenols (like spermidine, resveratrol, and quercetin)

  may support mild autophagy activation.

But nothing works as consistently or powerfully as a clean fasting window.

Timing: How Long to Fast for Autophagy?

• 12–16 hours: Mild autophagy begins

• 24 hours: Activity increases significantly

• 48+ hours: Deep clearance of damaged cells, higher regenerative effects

You don’t need to do extended fasts often.

Even regular intermittent fasting (16:8 or 18:6) supports autophagy enough to improve metabolic and immune function over time.

🔍 Expand Your Knowledge

📖 Scientific Articles

• Impact of intermittent fasting on health and disease processes

  🔗 Read here

🎥 Watch This

• Rare interview with Dr. Yoshinori Ohsumi on autophagy and cellular self-renewal

  🔗 Watch on YouTube

What’s Next?

In the next edition of our Fasting Series, we’ll explore how fasting interacts with stem cells, and why this connection could hold the key to reversing biological age.

To your health and vitality,
The Capilli Eternal Team

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Disclaimer:

This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.