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What if the key to a longer life was already written in our ancient genetic code?
A new human study suggests that a strong immune response to ancient viruses, called human endogenous retroviruses (HERVK), is linked to longevity.
The Discovery:
Researchers analyzed the genetic makeup of over 900 individuals and found that people who live to be 90 and older have a significantly higher frequency of specific HLA alleles. These alleles, which are part of our immune system's genetic code, bind more effectively to proteins from HERVK, suggesting that a robust immune response to these ancient viral elements may contribute to a longer lifespan.
The Science:
The study focused on HLA alleles, which are proteins that help the immune system distinguish between a body's own cells and foreign invaders.
It was discovered that 13 specific HLA alleles were enriched in a group of "very old" individuals (age 90 and up).
These specific alleles were found to bind with high affinity to proteins from HERVK, a family of ancient viruses embedded in our DNA.
The findings suggest that the interaction between our immune genes and these ancient viral elements is a crucial, and previously unstudied, factor in human longevity.
Your Action:
While cutting-edge therapies are emerging to modify our genetic code, your daily actions have an immediate and powerful impact on your health. This study underscores the importance of a healthy immune system throughout life. Focus on foundational habits like maintaining a balanced diet, getting adequate sleep, and regular exercise, all of which are proven to support a robust immune response and a healthy expression of your genetic code.
Bottom Line:
The way our immune system interacts with ancient viral DNA may be a key genetic factor in living a longer, healthier life.
Source:
Immunogenetics of longevity and its association with human endogenous retrovirus K, Frontiers in Aging, February 4, 2025
https://doi.org/10.3389/fragi.2025.1471202
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Disclaimer:
This newsletter is for informational purposes only and does not substitute professional medical advice. Always consult with a healthcare provider before making any changes to your health regimen.